Abstract
AbstractAndén, N. ‐E., T. Magnusson, B. ‐E. Roos and B. Werdinius. 5‐Hydroxyindoleacetic acid of rabbit spinal cord normally and after transection. Acta physiol. scand. 1965. 64. 193–196. – The normal spinal cord of rabbits was found to contain 0.20 μg/g 5‐hydroxyindolcacetic acid in the part cranially to Th4–Th6. Caudally the concentration was 71 per cent of that cranially. After transection at this level there was no significant change in the cranial part, when analyzed as a whole. Caudally to the lesion the 5‐hydroxyindoleacetic acid showed a substantial drop during the first 2 days and thereafter a gradual fall. It had disappeared almost completely after 10 days. The 5‐hydroxytryptamine, determined in the same rabbits, was unchanged after 2 days, was considerably reduced after 5 days, and had almost completely disappeared after 10 days. It is concluded that the level of 5‐hydroxyindoleacetic acid better than that of 5‐hydroxytryptamine mirrors the metabolic rate of 5‐hydroxytryptamine.
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