Abstract
Human beta defensins are widely expressed in the mucosal epithelial cells of organs and tissues.Beta defensins not only exhibit broad-spectrum antimicrobial activity against bacteria,fungi and enveloped virus,but also regulate immune response and inflammation.This research area has become a hot topic in recent years.The eyeball,as an exposed organ,is susceptible to all kinds of pathogens,resulting in infections and visual impairment.Over the past decade,several studies have demonstrated that,like many tissues in the body,the eye and its associated structures secrete and express beta defensins,which play an important role in the defense mechanism of the eye.In this review,we focus on the biological activities of beta defensins,their expression and distribution in the eye,their roles and potential applications in eye diseases. Key words: Anti-microbial peptide ; Beta-Defensin ; Ophthalmology
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