Abstract
The present study was carried out to understand the pattern of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism (rs4646994) among five ethnic groups of Punjab (North-West India), and other culturally and linguistically different Indian population groups. A total of 1012 unrelated individuals belonging to Banias, Brahmins, Jat Sikhs, Khatris and Scheduled Castes were genotyped for Alu ACE gene I/D polymorphism. ID genotype was observed to have highest frequency among all the studied population groups except among Scheduled Castes. The frequency of insertion (I) allele was higher in all the studied groups as compared to the frequency of deletion (D) allele, except in Brahmins. Out of the 10 possible pairwise comparisons, four population combinations show remarkable difference. Furthermore, on comparing these five ethnic groups with other Indian populations, discrepancy was observed in the allele frequency distribution, which can be accounted for variations in sample size, study design, geographical location and diverse ethnic background.
Published Version
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