Distribution Behavior of Metal 4-(2-Thienyl)-4-thioxo-1,1,1-trifluoro-2-butanonates in Reversed-Phase High-Performance Liquid Chromatography.

Abstract

For cobalt(III), nickel(II), copper(II) and zinc(II) 4-(2-thienyl)-4-thioxo-1, 1, 1-trifluoro-2-butanonates (STTA) the capacity factors in an octyl- or an octadecyl-bonded silica gel and a methanol-water system of reversed-phase high- performance liquid chromatography (RP-HPLC) were compared with the distribution ratios (DB) of those chelates in the batch method. The distribution behavior of the metal-STTA chelates in the batch method almost corresponded to the retention behavior of those in RP-HPLC. Moreover, the dependence of log DB on log[STTA] in the methanol-water phase of the batch method was almost consistent with the dependence of log D on log[STTA] in the organic phase in chelate extraction. These situations suggest that the distribution behavior of metal chelates in liquid-liquid extraction may be helpful to estimate their chromatographic behavior in RP-HPLC.