Distribution and mortality time trend of multiple sclerosis and some other diseases in Norway.

Abstract

Norwegian mortality data (underlying and contributory cause) from 1951–65 have been compiled for multiple sclerosis, paralysis agitans, and pernicious anemia. Disability pension data as of Jan. 1, 1966, have been adduced for the first two diseases and municipality rates computed. For amyotrophic lateral sclerosis underlying cause mortality is presented. Place of birth has been ascertained for those who died with multiple sclerosis. The emphasis is on the geographic distribution of multiple sclerosis and pernicious anemia. The findings of the present study broadly confirm those of previous studies of the two conditions. They have a similar, but apparently not identical, pattern. It is suggested that a test be made of the hypothesis that properties of the soil is involved in the etiology of multiple sclerosis. Six pairs of one high-risk and one low-risk municipality are proposed for investigation. Multiple sclerosis mortality has been declining during the period 1951–68. Paralysis agitans showed no distinct geographic pattern, although the county mortality variations were similar to those of multiple sclerosis. The mortality from paralysis agitans has not shown any decreasing tendency, and there is no convincing negative association with lung cancer.