Abstract
Objective To investigate the clinical distribution and drug resistance of carbapenems-resistant Klebsiella pneumoniae (CRKP). Methods A total of 134 clinical strains of CRKP were collected from inpatients in our hospital from January 2014 to December 2016. VITEK-2 compact automatic microbiological analyzer was used to identify the bacteria and the supporting gram-negative bacterial drug susceptibility card was used for susceptibility testing. The sensitivity of other clinical commonly used antimicrobial agents was measured by K-B method. And the clinical distribution of CRKP and its resistance to antimicrobial agents were investigated and analyzed. Results The clinical strains of CRKP were isolated mainly from urine (n=70, 52.2%) and sputum (n=38, 28.4%). Klebsiella pneumoniae was identified in samples from the department of neurosurgery, including neurosurgery ICU (47.8%, 64/134), ICU (23.9%, 32/134), department of hepatobiliary surgery (8.2%,11/134) and department of urology (6.0%, 8/134). Among all 22 antimicrobial agents tested, the resistant rates of CRKP to 16 antimicrobial agents were >90%, especially for ampicillin it was 100%, and those to 19 antibiotics were >80%, only for tigecycline it was 23.1%. There were 16 strains of CRKP with positive extended spectrum β-lactamases (ESBLs) (11.9%). All the CRKP strains were resistant to more than three kinds of antimicrobial agents, except one strain that was resistant to two kinds. Conclusion There is a wide range of clinical distribution of CRKP, which is resistant to most of antimicrobial agents, while tigecycline still has a strong antibacterial activity to CRKP. Key words: Klebsiella pneumoniae; Carbapenems; Drug resistance
Published Version
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