Abstract
PurposeGiven the lack of research on the left–right asymmetry of ovarian teratoma among Chinese patients, this study aimed to determine the lateral distribution and related clinical characteristics of Chinese ovarian teratoma patients treated at a single center.MethodsWe conducted a cross-sectional study of surgical patients pathologically diagnosed with ovarian teratomas in the gynecology inpatient department of the International Peace Maternity and Child Health Hospital in Shanghai between July 2006 and July 2018.ResultsOf the 4417 patients with ovarian teratoma, 3835 were finally analyzed. There were 2030 (53.24%) cases of right-sided benign ovarian teratoma versus 1783 (46.76%) cases of left-sided benign teratoma (P < 0.001). The recurrence rate of benign ovarian teratoma was 4.2%; recurrence occurred more often on the left side (left vs. right = 55 vs. 45%, P = 0.033). Compared with the right-sided ovarian teratoma patients, left-sided ones had significantly high recurrence risk (OR 1.430; 95% CI 1.03–1.99). The rate of ovarian torsion in patients with ovarian mature cystic teratomas (MCTs) during intrauterine pregnancy was 3.17 versus 1.72% in non-pregnant MCT patients (P = 0.049). For those MCT patients with intrauterine pregnancy, ovarian torsion occurs more often on the right side (left vs. right = 16.67 vs. 83.33%, P = 0.028).ConclusionThis study confirms a distinctive right-side dominance of benign ovarian teratomas. Compared with the right side, recurrent ovarian teratomas occur more often on the left side, requiring close follow-up. Intrauterine pregnancy may increase the risk of ovarian torsion, particularly on the right side, in MCT patients.
Highlights
Ovarian teratomas (OTs) are the most common neoplasms of the ovary, constituting 10–20% of all ovarian tumors in adults and almost half of all ovarian tumors in children, and these tumors originated from three layers, namely ectoderm, mesoderm, and endoderm [1, 2]
OTs could be classified as mature cystic teratomas (MCTs), monodermal
Understanding the left–right asymmetry of OTs could help us develop a follow-up plan for patients and prevent OT recurrence and ovarian torsion caused by OTs
Summary
Ovarian teratomas (OTs) are the most common neoplasms of the ovary, constituting 10–20% of all ovarian tumors in adults and almost half of all ovarian tumors in children, and these tumors originated from three layers, namely ectoderm, mesoderm, and endoderm [1, 2]. Inferior vena cava thrombosis can cause serious complications such as pulmonary embolism that can be life-threatening [9, 10]. Another rare but serious complication of OTs is anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, which results in a characteristic syndrome presenting with prominent psychiatric symptoms or, less frequently, memory deficits, followed by a rapid decline of the level. Understanding the left–right asymmetry of OTs could help us develop a follow-up plan for patients and prevent OT recurrence and ovarian torsion caused by OTs. results of all aforementioned studies were based on a relatively small sample size and different populations, focused only on MCTs, and barely have information of the lateral distribution of OTs in China. Given the lack of research on the right-left asymmetry of OT among Chinese patients, this hospital-based cross-sectional study aimed to determine the lateral distribution and related clinical characteristics of Chinese OT patients in a single center
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
