Abstract
N-methyl-D-aspartate receptors (NMDAR) form a diverse class of heterotetrameric ionotropic receptors whose activation by the coincidence of glycine and glutamate binding is critical for both basal neuronal transmission and plasticity characteristic of learning and memory. Dysregulation is implicated in the pathological mechanisms of a wide array of neurological disorders including schizophrenia, stroke, neurodegenerative diseases, epilepsy, and depression. Electrophysiological measurement of single channel opening and closing dynamics has enabled the construction of complex models that predict trajectories through many states and structural studies have begun to reveal multiple conformations.
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