Abstract
BackgroundEarly gastric carcinoma is heterogeneous and can be divided into early gastric cardiac carcinoma (EGCC) and early gastric non-cardiac carcinoma (EGNCC) groups. At present, differences in clinicopathology remains obscure between EGCC and EGNCC fundus–corpus and antrum–angularis–pylorus subgroups, especially between EGCC with and without oesophageal invasion.MethodsIn this study, we studied 329 consecutive early gastric carcinoma radical gastrectomies with 70 EGCCs and 259 EGNCCs.ResultsCompared to the EGNCC antrum–angularis–pylorus (n = 181), but not fundus–corpus (n = 78), sub-group, EGCC showed significantly older age, lower prevalence of the grossly depressed pattern, better tumor differentiation, higher percentage of tubular/papillary adenocarcinoma, but lower frequency of mixed poorly cohesive carcinoma with tubular/papillary adenocarcinoma, and absence of lymph node metastasis (LNM) in tumors with invasion up to superficial submucosa (SM1). In contrast, pure poorly cohesive carcinoma was less frequently seen in EGCCs than in EGNCCs, but mixed poorly cohesive carcinoma with tubular/papillary adenocarcinomas was significantly more common in the EGNCC antrum–angularis–pylorus sub-group than in any other group. No significant differences were found between EGCC and EGNCC sub-groups in gender, tumor size, H. pylori infection rate, and lymphovascular/perineural invasion. EGCC with oesophageal invasion (n = 22), compared to EGCC without (n = 48), showed no significant differences in the H. pylori infection rate and oesophageal columnar, intestinal, or pancreatic metaplasia, except for a higher percentage of the former in size > 2 cm and tubular differentiation.ConclusionsThere exist distinct clinicopathologic differences between EGCC and EGNCC sub-groups; EGCC was indeed of gastric origin. Further investigations with larger samples are needed to validate these findings.
Highlights
Gastric carcinoma is heterogeneous and can be divided into early gastric cardiac carcinoma (EGCC) and early gastric non-cardiac carcinoma (EGNCC) groups
It remains elusive about the differences in the risk of lymph node metastasis (LNM) between early gastric cardiac carcinoma (EGCC) and early gastric non-cardiac carcinoma (EGNCC)
The aims of the present study were to investigate clinicopathology and risk of LNM in Early gastric carcinoma (EGC) arising in the gastric cardia, fundus–corpus, and antrum–angularis– pylorus regions in patients treated at our center in the Jiangsu Province, which is one of gastric cancer endemic regions in China
Summary
Gastric carcinoma is heterogeneous and can be divided into early gastric cardiac carcinoma (EGCC) and early gastric non-cardiac carcinoma (EGNCC) groups. The current selection criteria for endoscopic therapy are mainly based on the risk of lymph node metastasis (LNM) in patients with EGC [3] It remains elusive about the differences in the risk of LNM between early gastric cardiac carcinoma (EGCC) and early gastric non-cardiac carcinoma (EGNCC). Previous studies have shown that advanced gastric cardiac cancer may have clinicopathological features and pathobiological behaviors distinctly different from gastric non-cardiac cancer because of higher pT and pN stages and poorer prognosis [4, 5] We hypothesized that these differences may be related, at least in part, to various mucosal epithelial cell types housed in 3 different gastric regions: cardia, fundus–corpus, and antrum–angularis– pylorus. The aims of the present study were to investigate clinicopathology and risk of LNM in EGC arising in the gastric cardia, fundus–corpus, and antrum–angularis– pylorus regions in patients treated at our center in the Jiangsu Province, which is one of gastric cancer endemic regions in China
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
