Abstract
Background/Aims: The association between initial phase of gastric emptying and clinical symptoms and depression status in functional dyspepsia has not been studied in detail. Methods: The subjects were 20 patients with Rome III-based functional dyspepsia and healthy volunteers. We evaluated upper abdominal symptoms using GDSS score and used Self-Rating Questionnaire for Depression (SRQ-D) scores to determine depression status. Gastric motility was evaluated with the 13C-acetate breath test.
Highlights
Functional dyspepsia (FD) has been subclassified into two new disease categories under the Rome III classification criteria: epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS) [1]
Delgado-Aros et al have reported that rapid initial 1hr gastric emptying in 43% of FD patients, and associated gastric hypersensitivity with this type of emptying [33]
It seems to be useful to estimate initial gastric emptying within 15 mins using AUC15 value or AUC15/AUCinf as well as the maximal excretion (Tmax) value in FD patients
Summary
Functional dyspepsia (FD) has been subclassified into two new disease categories under the Rome III classification criteria: epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS) [1]. Impairment of gastric motility such as gastric emptying is strongly associated with the pathophysiology of FD, one of the most common gastrointestinal disorders [12]. Several studies have reported that gastric motility was associated with psychogenic factors in FD patient’s [13,14]. We have previously reported that Tmax value as a marker of gastric emptying in PDS patients was significantly greater compared with that of healthy volunteers [15]. We have reported that prokinetics like mosapride citrate improves clinical symptoms by affecting the Tmax value in proton pump inhibitor (PPI)-resistant NERD patients with impaired gastric emptying [16]. We have reported that nizatidine administration significantly improved both gastric emptying and clinical symptoms in FD patients with impaired gastric emptying [17]. We have considered that Tmax value using 13C-acetate breath test were the useful marker for treatment of FD patients
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