Abstract
A novel control method with an automatic tuning of PID controller parameters was used for a better regulation of dissolved oxygen concentration (DOC) in fed-batch fermentations of E. coli. Agitation speed (RPM) and the oxygen partial pressure in the inlet gas stream were manipulated. In this method, heuristic reasoning allows improved tuning decisions to be made based upon the supervision of certain control performance indices in the same cognitive manner as in expert control, which obviates the need for assumptions about the process or disturbance patterns. The disturbing effect of feed rate changes is compensated for by using a feedforward scheme. The specific growth rate was controlled by manipulating the feed flow rate using a feedforward controller supplemented with integral feedback action.
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