Abstract
Benzoic acid crystals were ground with microcrystalline cellulose. In order to evaluate the hydrogen-bond matrix of cellulose in the ground mixture, dissolution experiments were carried out using organic solvents as dissolution media. With prolongation of grinding, benzoic acid was gradually amorphized and the dissolution of benzoic acid from the ground sample was significantly suppressed in cyclohexane. This result was considered to be due to the dispersion of benzoic acid molecules in the hydrogen-bond matrix of cellulose through the grinding process. From experiments using a series of organic solvents, it was found that the amount of benzoic acid dissolved was correlated to the polarity of solvents. On the other hand, moisture in the solvent and primary hydroxyl groups in solvent molecules were considered to be effective factors for enhancing the dissolution of benzoic acid from the ground mixture.
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