Dissolution properties of different compositions of biphasic calcium phosphate bimodal porous ceramics following immersion in simulated body fluid solution

Abstract

Biphasic calcium phosphate (BCP) bimodal porous ceramics were prepared from a mixture of fine powders of hydroxyapatite (HAp) and beta-tricalcium phosphate (β-TCP) with varying HAp/β-TCP ratios. Two types of HAp powders and one type of β-TCP powder were used to produce porous BCP bioceramics with HAp/β-TCP weight ratios of 20/80, 40/60, and 80/20. Dissolution tests were performed to compare the dissolution properties of BCP-based bioceramics with different structural properties. Porous ceramic samples of approximately 0.5 g were individually soaked in 30 ml of simulated body fluid (SBF) solution at 36.5 °C for 1, 3, 7 and 10 days, respectively. The calcium content of the SBF solution was analyzed by ICP. The porous bodies were filtered, dried, and characterized using SEM, XRD, and FT-IR. The results indicate that the sample structural properties seem to have a greater effect than the storage environment on the dissolution properties.