Abstract
AbstractThe efficiency of interactive powder mixtures as a process used to increase the dissolution rate of poorly soluble drugs is dependent on the degree and extent of dispersion of drug agglomerates into individual particles. Furthermore, the dispersion mechanism is dependent on the surface characteristics of excipient particles.The smooth excipient particles produce interactive powder mixture with high dissolution efficiency for poorly soluble drugs. In contrast, when the excipient particulate surfaces have high rugosity, the corresponding interactive powder mixtures produce lower dissolution efficiency. The main reason is the entrapment of drug particles and agglomerates into the indentations already present on excipient particulate surfaces. When the entrapment sites are blocked with fine excipient particles the dissolution efficiency increases significantly. Therefore, surface characteristics of excipient particles should be examined carefully before formulation of solid dosage forms using interact...
Published Version
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