Abstract

Lateral hypothalamic stimulation in rats produces both rewarding and analgesic effects. In comparison to the rewarding effect, significantly higher current intensities were required to produce analgesia as measured by the hot-plate method. The analgesia did not outlast stimulation. Alpha-methyl-p-tyrosine (250 mg/kg) decreased self-stimulation rates but had no effect on stimulation-induced analgesia. It was concluded that the rewarding and analgesic effects of lateral hypothalamic stimulation involve separate neurochemical systems.

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