Abstract
Recently, Vesuna et al. proposed a novel circuit mechanism underlying dissociative states using optogenetics and pharmacology in mice in combination with intracranial recordings and electrical stimulation in an epilepsy patient. Specifically, the authors identified a posteromedial cortical delta-rhythm that underlies states of dissociation. In the following, we would like to critically review these findings in the context of the human literature on dissociation as well as highlight the challenges in translational neuroscience to link complex behavioral phenotypes in psychiatric syndromes to circumscribed circuit mechanisms.
Highlights
Reviewed by: Edward Mann, University of Oxford, United Kingdom Charles H
Dissociative states can be elicited by pharmacological manipulations and are a signature of neurological conditions, such as epilepsy
Vesuna et al observed that ketamine selectively reduced only paw-licking which was correlated with a 1–3 Hz rhythm in posteromedial cortex that was selectively coupled to thalamic circuits
Summary
Reviewed by: Edward Mann, University of Oxford, United Kingdom Charles H. Vesuna et al [1] proposed a novel circuit mechanism underlying dissociative states. The authors administered ketamine, a dissociative anesthetic, to mice and obtained electrophysiological recordings from several brain regions, including retrosplenial cortex.
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