Abstract
Invasive fungal infections (IFI) are a primary cause of morbidity and mortality in patients with haematological malignancies. We describe an unusual clinical and radiological presentation of invasive mucormycosis (IM) in a 69-year-old patient with relapsed acute myeloid leukaemia (AML). The patient was diagnosed with disseminated IM with involvement of the central nervous system (CNS ) in an atypical location, lung, spleen, muscle, bone and heart, after having completed induction and bridging chemotherapy to allogeneic haematopoietic stem cell transplant (HSCT). Her clinical presentation was atypical with mild neurological symptoms slowly progressing over two months and without appropriate signs of systemic inflammation. Mucorales was eventually confirmed from bronchoalveolar lavage and subdural collection. This report highlights the difficult challenges of managing disseminated IM in an immunocompromised patient, where close multi-disciplinary specialist care enabled successful treatment, followed by T-cell depleted allogeneic HSCT for a high-risk haematological malignancy.
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