Abstract
HERPES simplex virus (HSV) can cause overwhelming neonatal infection even when antiviral therapy is initiated at the first sign of illness. 1-3 Thus, antiviral prophylaxis has been recommended for high-risk neonates, 1,3 including those delivered vaginally or by See also pp 1051,1056, and 1067. cesarean section (after membranes have been ruptured for more than four hours) to mothers with primary HSV genital infections. 4 This case report describes a high-risk neonate who developed disseminated HSV infection despite antiviral prophylaxis. Report of a Case A 24-year-old woman presented to the hospital 24 hours after rupture of membranes. She was at term and had been followed up for 32 weeks in the obstetrics clinic. She had had intercourse seven days before rupture of membranes. She had no history of HSV infection and no known exposure to HSV. On admission, her only complaint was vaginal pain and burning of two days' duration. Physical
Published Version
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