Abstract
Dissecting the Axoneme Interactome: The Mammalian Orthologue of Chlamydomonas PF6 Interacts with Sperm-Associated Antigen 6, The Mammalian Orthologue of Chlamydomonas PF16
Highlights
The axoneme central apparatus is thought to control flagellar/ciliary waveform and maintain the structural integrity of the axoneme, but proteins involved in these processes have not been fully elucidated
We characterized the human and murine orthologues of PF6 and demonstrated that the murine Pf6 gene is expressed in a pattern consistent with a role in flagella and cilia and that PF6 protein is localized to the central apparatus of the sperm flagellar axoneme
We discovered that murine PF6 directly associates with the mammalian orthologue of Chlamydomonas PF16 (SPAG6)1 [12], a central apparatus protein that is localized to the C1 microtubule in algae
Summary
The axoneme central apparatus is thought to control flagellar/ciliary waveform and maintain the structural integrity of the axoneme, but proteins involved in these processes have not been fully elucidated. We characterized the human and murine orthologues of PF6 and demonstrated that the murine Pf6 gene is expressed in a pattern consistent with a role in flagella and cilia and that PF6 protein is localized to the central apparatus of the sperm flagellar axoneme.
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