Disrupted Corollary Discharge in Schizophrenia: Evidence From the Oculomotor System

Abstract

Corollary discharge (CD) signals are motor-related signals that exert an influence on sensory processing. They allow mobile organisms to predict the sensory consequences of their imminent actions. Among the many functions of CD is to provide a means by which we can distinguish sensory experiences caused by our own actions from those with external causes. In this way, they contribute to a subjective sense of agency. A disruption in the sense of agency is central to many of the clinical symptoms of schizophrenia, and abnormalities in CD signaling have been theorized to underpin particularly those agency-related psychotic symptoms of the illness. Characterizing abnormal CD associated with eye movements in schizophrenia and their resulting influence on visual processing and subsequent action plans may have advantages over other sensory and motor systems. That is because the most robust psychophysiological and neurophysiological data regarding the dynamics and influence of CD as well as the neural circuitry implicated in CD generation and transmission comes from the study of eye movements in humans and nonhuman primates. We review studies of oculomotor CD signaling in the schizophrenia spectrum and possible neurobiological correlates of CD disturbances. We conclude by speculating on the ways in which oculomotor CD dysfunction, specifically, may invoke specific experiences, clinical symptoms, and cognitive impairments. These speculations lay the groundwork for empirical study, and we conclude by outlining potentially fruitful research directions.