Abstract
Abstract Information regarding pharmacokinetic disposition of drugs in ostriches (Struthio camelus) is very scarce. Three common veterinary nonsteroidal anti-inflammatory drugs (sodium salicylate, SA; flunixin, FLU; and meloxicam, MEL) were administered intravenously to young ostriches. Plasma concentrations of the drugs were determined by validated high-performance liquid chromatography methods and pharmacokinetic parameters were calculated. After intravenous administration of SA (25 mg/kg), FLU (1.1 mg/kg), and MEL (0.5 mg/kg), these drugs were eliminated from plasma with mean half-lives of 1.32, 0.17, and 0.5 hours, respectively. Apparent volumes of distribution (0.36 L/kg, 0.13 L/kg, and 0.58 L/kg, respectively) indicated that tissue distribution was limited for the 3 drugs. Total body clearance was 0.19 L/h·kg for SA and 0.50 and 0.72 L/kg·h for FLU and MEL, respectively. These nonsteroidal anti-inflammatory drugs, especially FLU and MEL, are rapidly cleared from the ostrich body.
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