Abstract
Novel disposable screen-printed electrodes modified with silicon dioxide nanoparticles were developed for the electrochemical determination of temozolomide and its interaction with DNA. The characterization of silicon dioxide nanoparticles (SiNPs) was conducted by transmission electron microscopy and energy-dispersive x-ray spectroscopy (EDX). The EDX measurements show that the silicon nanoparticles consisted of 53.08% oxygen (O) and 46.92% silicon (Si), confirming their purity. Chemical characterization was conducted using Fourier transform infrared spectroscopy. Surface characterization of SiNPs-modified screen-printed electrodes was performed using atomic force microscopy. SiNP modification was demonstrated to increase the electrode surface area by 2.3-folds, from 0.75 × 10−3 cm2 to 1.75 × 10−3 cm2, resulting in an enhanced signal. The detection limit was 5.6 µg/mL for temozolomide and 7.2 µg/mL for DNA, respectively. The linear concentration range was from 18.6 to 200 µg/mL for temozolomide and 23.9 to 80 µg/mL for DNA.
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