Abstract
Cellular survival requires the ion gradients built by the Na+/K+-pump, a member of the P-type 2 ATPase subfamily, which includes structurally similar enzymes with catalytic subunits containing 10 transmembrane segments (TM1-TM10), like the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA). Both enzymes alternate between phosphorylated and dephosphorylated states of two major conformations, the cytoplasmic-facing E1 and extracytoplasmic-facing E2. Despite their similarities, the TM1-TM2 region of SERCA moves in a piston-like manner as SERCA opens to release Ca2+ to the luminal side.
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