Dispersive solid phase extraction of several pesticides from fruit juices using a hydrophobic metal organic framework prior to HPLC-MS/MS determination

Abstract

A metal organic framework (MOF)-based dispersive solid phase extraction procedure was introduced using a hydrophobic sorbent for the extraction of multi class pesticides from fruit juice samples prior to their determination by high performance liquid chromatography-tandem mass spectrometry. For this purpose, NH2-UiO-66(Zr) MOF was synthesized by a hydrothermal approach. Then the sorbent was silylated and used in the extraction procedure. The extraction procedure was done by using 7 mg of the sorbent from 5 mL of a sample solution containing the analytes. After that, the extracted analytes were eluted and preconcentrated by vaporizing the elution solvent. The method was linear within the range of 0.29–500 ng mL−1. The limits of detection, intra- and inter-day relative standard deviations, and extraction recoveries were in the ranges of 0.02–0.1 ng mL−1, 2.9–8.8%, 6.8–14.4%, and 74–89%, respectively. Performing the method on the selected samples showed that they were free of the analytes. This method can help to monitor the studied pesticides in juice samples as well as improving the safety of foods.