Abstract
The differences that exist between the CD4 count strata at which certain opportunistic infections occur in sub Saharan Africa suggest that targeting prophylaxis at HIV patients in this part of the world based on data generated from developed countries may be one of the reasons why there is high HIV-related morbidity in Africa. The aim of this study was to investigate the changing incidence of some AIDS defining illnesses in Northern and Southern parts of Nigeria, relating them to different CD4 count strata.
Highlights
The differences that exist between the CD4 count strata at which certain opportunistic infections occur in sub Saharan Africa suggest that targeting prophylaxis at HIV patients in this part of the world based on data generated from developed countries may be one of the reasons why there is high HIV-related morbidity in Africa.The aim of this study was to investigate the changing incidence of some AIDS defining illnesses in Northern and Southern parts of Nigeria, relating them to different CD4 count strata
Disparities in the prevalence of AIDS related opportunistic infections in Nigeria- implications for initiating prophylaxis based on absolute CD4 Count
All the opportunistic infections occurred at higher rates in CD4 counts less than 200cells/ul (p < 0.0001) except for tuberculosis which occurred highest at CD4 counts >200cells/ul (16 out of the 24 positive sputum smears were recovered in patients with CD4 counts >200 cells/ul)
Summary
The differences that exist between the CD4 count strata at which certain opportunistic infections occur in sub Saharan Africa suggest that targeting prophylaxis at HIV patients in this part of the world based on data generated from developed countries may be one of the reasons why there is high HIV-related morbidity in Africa.The aim of this study was to investigate the changing incidence of some AIDS defining illnesses in Northern and Southern parts of Nigeria, relating them to different CD4 count strata.
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