Abstract
We modeled the consequences of explosion-induced coal-mine trauma, ECMT, i.e., contusion, intoxication by explosion products, burns, emotional stress, etc., in rats using a specially developed device. ECMT was produced by a dosed explosion of a methane-air mixture. In addition, the device allowed us to model effects of coal-mine occupational factors, CMOF (high air pressure, temperature, and humidity, high contents of dust and alien gases in the air, and intensive physical loading). We examined modifications of microcirculation in the vessels of the abdominal cavity (mesenterial vessels) after ECMT and after such a trauma aggravated by the premorbid action of CMOF (for 1 h daily over 14 days). The long-lasting influence of CMOF evoked noticeable vasoconstriction and a drop in the volume velocity of blood flow through the mesenteric vessels. Both complicated and noncomplicated ECMT resulted in significant dilatation of the mesenteric vessels (their mean diameter increased in 1 h by about 40% as compared with the norm) and an increase in the volume blood flow velocity (by 71 and 41% as compared with the norm, respectively). Injections of 3 mg/kg diazepam (i.p., immediately after ECMT) considerably corrected the shifts of the pressure in and linear velocity of blood flow through the microvessels under study, whereas their diameter and the volume flow velocity remained increased (the former, somewhat, and the latter, significantly). The mechanisms of disorders of regional circulation evoked by the actions of ECMT and CMOF in the visceral microvessels (with special attention to metabolic factors, which evoke vasodilation), the importance of the phenomenon of blood sequestration in these vessels to the clinical course of ECMT, and approaches for pharmacological correction of the above disorders by drugs of the benzodiazepine family are discussed.
Published Version
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