Abstract
This talk will present a synthesis of findings from theory, computation, and experiment highlighting the roles of intrinsically disordered regions as regulators and modulators of phase transitions for linear multivalent proteins. These phase transitions determine the organization, dynamics, and functions of membraneless organelles and other biomolecular condensates. The insights obtained are paving the way for designing condensates with bespoke sequence‐encoded phase behavior and material properties.Support or Funding InformationThis work is supported by the National Science Foundation, the National Institutes of Health, the Human Frontier Science Program, and the St. Jude Children's Research Hospital Research Collaborative.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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