Abstract
Disintegration Properties and Drug Release Profiles of Sodium Alginate Films Containing Rebamipide
Highlights
Sodium alginate [Alg-Na], an algal polysaccharide consisting of α-L-guluronate and β-D- mannuronate, is used as a food ingredient [1]
RM mouthwash has been used to treat oral mucositis induced by chemoradiotherapy and radiotherapy [11,12,13], and some attempts have been made to deliver RM to the local disease site [14,15]
We have reported Alg-Na as a useful polymer for preparing FDs, because thin films can be formed using this polysaccharide as a film base by simple methods that do not require dissolution in organic solvents [16]
Summary
Sodium alginate [Alg-Na], an algal polysaccharide consisting of α-L-guluronate and β-D- mannuronate, is used as a food ingredient [1]. Film Dosage Forms [FDs] prepared using water-soluble polymers are a strategy for drug delivery to local disease sites. We prepared FDs incorporating rebamipide as a model drug using various types of sodium alginates [Alg-Nas] as the film base via the casting method.
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