Comparative Evaluation of Isoniazid and Rifampicin Dispersible Tablets Prepared by Direct Compression and Sublimation Methods

Abstract

Dispersible tablets are gaining popularity over conventional tablets due to its increased popularity for administration to pediatric and geriatric patients as it provides quick onset of action and ease of administration. An attempt had been made, to develop dispersible tablet of isoniazid and rifampicin combination by direct compression and sublimation method, to increase the bioavailability of the anti-tubercular agents as well to provide the local delivery in the case of oral tuberculosis. Formulation F1 to F8 (2% and 4% w/w of different superdisintegrants (crospovidone, pregelatinized starch, croscarmellose sodium and sodium starch glycolate) formulated by direct compression method. The formulations containing 4% of superdisintegrants (F2, F4, F6, and F8) were selected as optimized and hence 4% of superdisintegrants were used for sublimation method (F9 to F12). The effects of sublimating material (camphor) on drug release profile and disintegration property were evaluated. Studies on two different methods showed sublimation method as a better alternative as its formulations rapidly disintegrates, disperse and shows faster drug release (in 14 min) in comparison to direct compression (in 20 min). Pre-compression parameters of formulation blends indicated good flow properties and compressibility. Simultaneous estimation was performed for calculation of drug content and % drug release. In vitro release data analysis revealed 90% drug release. F9 formulation (sublimation) showed best anti-tubercular activity. F2, F9 formulations were found to be stable even after 90 days. Hence it is evident from this study that fast dissolving tablets could be a promising delivery system for isoniazid and rifampicin with improved drug availability and better patient compliance.