Abstract
Publisher Summary This chapter provides an overview on the recent development in the field of blood cell calcium studies. It discusses the active calcium transport in red cells and the calcium-induced potassium transport. The chapter presents the general characteristics of the red cell calcium pump, its molecular basis, possible working mechanism, and cellular regulation. It discusses the experiments on the action of calmodulin and proteolytic digestion on the calcium pump in inside-out red cell membrane vesicles. A calmodulin-binding, trypsin-sensitive regulatory subunit of the calcium pump at the internal membrane surface has been suggested. In addition to the known effects of internal cations, external Na and K ions also may regulate the activity of calcium pumping. Finally, the conclusion is made on the basis of the available data no safe decision can be made for any of the proposed molecular entities.
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