Abstract
In an operant procedure of lever pressing on a FR10 schedule of food reinforcement, male hooded rats were trained to respond on a lever on one side of a food cup following a desipramine (10 mg/kg) injection and to respond on a lever on the other side following a saline injection. Sixty percent of the rats learned to reliably discriminate desipramine from saline. The rate of lever pressing at this dose of desipramine was 49% of the saline response rate. No tolerance to this depressant effect was observed after 20 injections. Subjects selected the appropriate desipramine lever 91, 29 and 18% of the time following 10, 2.5 and 0 (saline) mg/kg of desipramine. Imipramine and protryptyline each produced 50% selection of the desipramine lever at a dose of 40 mg/kg. Lower doses were less effective. d-Amphetamine produced 20 and 67% desipramine lever selection at 0.64 and 1.25 mg/kg respectively.
Published Version
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