Abstract

Significant prevalence and multifactorial occurrence of psoriasis are the main reasons why this disease has been studied for years by scientists in the field of dermatology. Finding tools to predict the occurrence and severity of this disease is one of the key unrealized areas of modern medicine in the field of skin diseases. The purpose of the study is to build and analyze discriminant models of the possibility and features of psoriasis course in Ukrainian men without and taking into account the somatotype, depending on the structure and size of the body. Anthropometric and somatotypological examination of 82 practically healthy and 100 patients with mild and severe psoriasis was performed. Construction of discriminant models of the possibility of occurrence and features of psoriasis depending on anthropo-somatotypological indicators is performed in the license package “Statistica 5.5”. It was found that men of the general group and representatives of the mesomorphic somatotype can reliably interpret the obtained classification indicators both between healthy and patients with psoriasis of different course, and between men with psoriasis of mild and severe course (correctness 84.1% of cases, statistics Wilks’ Lambda=0.074, р<0.001 in the general group, correctness 83.6% of cases, statistics Wilks’ Lambda=0.077, р<0.001 in mesomorphic somatotype). In men of endo-mesomorphic somatotype, a reliable interpretation of the obtained classification indicators is possible only between healthy and psoriatic men (correctness 84.6%, statistics Wilks’ Lambda=0.027, р<0.001). Discriminant models in men of the general group include body diameters and SFT (44.4% each) and the fat component of body weight (11.1% each); in men of mesomorphic somatotype – body diameters (57.1%), SFT (28.6%) and body surface area (14.3%); in men of endo-mesomorphic somatotype – body diameters (60.0%) and SFT on the thigh and the height of the finger anthropometric point (20.0% each). The greatest contribution to discrimination in men of the general group and representatives of the mesomorphic somatotype is made by shoulder width, and in men of endo-mesomorphic somatotype – shoulder width, interspinous and intercristal distances. The results obtained, especially in the division of men into somatotypes, indicate a high genetic predisposition to psoriasis.

Highlights

  • More than 200 years have passed since the first detailed clinical description of psoriasis and its isolation as a separate disease by the "father" of modern dermatology Robert W illan

  • In Northern India, the prevalence of psoriasis among children is 0.0002%, and the peak incidence occurs at the age of 6-10 years in boys and 11-15 years in girls; a positive family history was found in 9.8-28.0% of respondents [12]

  • Given the distribution of healthy men with psoriasis of mild and severe course by somatotypes according to the Heath-Carter scheme [7]: endomorphs - respectively 2-00; mesomorphs - respectively 39-28-55; ectomorphs - 90-2, respectively; ecto-mesomorphs - 13-0-2, respectively; endo-mesomorphs - respectively 13-4-9; representatives of the middle intermediate somatotype - respectively 6-00; only representatives of mesomorphic and endomesomorphic somatotypes were selected for further modeling of the possibility of occurrence and peculiarities of psoriasis course

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Summary

Introduction

More than 200 years have passed since the first detailed clinical description of psoriasis and its isolation as a separate disease by the "father" of modern dermatology Robert W illan ( the outdated name of psoriasis Willan'slepra). Since researchers have not been able to say for sure what is the trigger for this disease, which drug treatment will get rid of it or prevent its occurrence. It is still only known that psoriasis is a chronic inflammatory immune-mediated proliferative disease that mainly affects the skin, joints and nails. Such significant attention to psoriasis is primarily due to the high prevalence of this disease. Discriminant models of the possibility of occurrence and course of psoriasis in men of the general group and. Data from many studies indicate that 2 to 3% of the world's population suffers from psoriasis. The prevalence is heterogeneous in different regions of the world. In Northern India, the prevalence of psoriasis among children is 0.0002%, and the peak incidence occurs at the age of 6-10 years in boys and 11-15 years in girls; a positive family history was found in 9.8-28.0% of respondents [12]

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