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https://doi.org/10.1016/j.bmcl.2011.01.075
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Cite Publication Date: Jan 22, 2011 | |
 Citations: 6 |
Affiliation: Sunesis (United States)
A series of N-(pyrimidin-4-yl)-phenylalanine VLA-4 antagonists is described. Optimization of substituents at the 2 and 5 positions of the pyrimidine ring gave 14, a very potent VLA-4 inhibitor which is orally active in a sheep asthma model.
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