Discovery and Replication of Time-Resolved Functional Network Connectivity Differences in Adolescence and Adulthood in over 50K fMRI Datasets.

Abstract

There remains an open question about whether and in what context brain function varies in adolescence and adulthood. In this work, we systematically study the functional brain networks of adolescents and adults, outlining the significant differences in the developing brain detected via time-resolved functional network connectivity (trFNC) derived from a fully automated independent component analysis pipeline applied to resting-state fMRI data in over 50K individuals. We then statistically analyze the transient, recurrent, and robust brain state profiles in both groups. We confirmed the results in independent replication datasets for both groups. Our findings indicate a strengthening of a state reflecting functional coupling within the visual, motor, and auditory domains and anticorrelation with all other domains in a unique adult state profile, a pattern consistently less modular in adolescents. This new insight into possible integration, strengthening, and modularization of resting-state brain connections beyond childhood convergently indicates that the highlighted temporal dynamics likely reflect robust differences in brain function in adolescents versus adults.