Abstract
BackgroundRecent research has provided fascinating indications and evidence that the host health is linked to its microbial inhabitants. Due to the development of high-throughput sequencing technologies, more and more data covering microbial composition changes in different disease types are emerging. However, this information is dispersed over a wide variety of medical and biomedical disciplines.DescriptionDisbiome is a database which collects and presents published microbiota-disease information in a standardized way. The diseases are classified using the MedDRA classification system and the micro-organisms are linked to their NCBI and SILVA taxonomy. Finally, each study included in the Disbiome database is assessed for its reporting quality using a standardized questionnaire.ConclusionsDisbiome is the first database giving a clear, concise and up-to-date overview of microbial composition differences in diseases, together with the relevant information of the studies published. The strength of this database lies within the combination of the presence of references to other databases, which enables both specific and diverse search strategies within the Disbiome database, and the human annotation which ensures a simple and structured presentation of the available data.
Highlights
Recent research has provided fascinating indications and evidence that the host health is linked to its microbial inhabitants
Disbiome is the first database giving a clear, concise and up-to-date overview of microbial composition differences in diseases, together with the relevant information of the studies published. The strength of this database lies within the combination of the presence of references to other databases, which enables both specific and diverse search strategies within the Disbiome database, and the human annotation which ensures a simple and structured presentation of the available data
Seen the exploding data of microbiome alterations in different disease states, we present the Disbiome database, collecting and organizing this information
Summary
Recent research has provided fascinating indications and evidence that the host health is linked to its microbial inhabitants. Due to the development of high-throughput sequencing technologies, more and more data covering microbial composition changes in different disease types are emerging. This information is dispersed over a wide variety of medical and biomedical disciplines. It has been estimated that this ratio between microbial and human cells is closer to 1:1 [2]. The collection of these microorganisms is termed ‘microbiota’ and the collective genomes of all the microorganisms of these microbiota are defined as the microbiome [3]. The microbiome composition can change due to Janssens et al BMC Microbiology (2018) 18:50
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