Abstract
The disaggregation of biospecifically interacting particles in shear flow is studied on the basis of kinetic modeling of formation and breakup of ligand–receptor bonds. The reaction rate theory is employed to improve earlier estimations of the critical force required to separate the surfaces. A chain of particles connected through ligand–receptor bonds responds to an external load as a contorted elastic rod. The breakup of the many-particle aggregate is attributed to the rupture of the backbone rod-like chain of particles. The theoretical model is found to be in good agreement with our experimental data on disaggregation of particles of latex immunoconjugates and blood platelets in shear flow.
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