Directional versus omnidirectional Deep Brain Stimulation: Results of a multi-cente prospective blinded crossover study

Alfons Schnitzler ,Monika Pötter‐Nerger ,Andrew Evans ,Ramiro Álvarez ,Nestor Tomycz ,Saskia K Nagel ,Matthew Brodsky ,Pablo Mir ,Julie G Pilitsis ,Winona Tse ,Sergiu Groppa ,Fátima Carrillo ,Leo Verhagen ,Florence Defresne ,Binith Cheeran ,Leonardo Almeida ,Marta Blázquez ,Christian Hartmann ,Edward Karst ,Stefan Jun Groiss ,Joohi Jimenez‐Shahed ,Jan Vesper

doi:10.1016/j.parkreldis.2020.06.084

Directional versus omnidirectional Deep Brain Stimulation: Results of a multi-cente prospective blinded crossover study

Alfons Schnitzler , Monika Pötter‐Nerger + Show 20 more

https://doi.org/10.1016/j.parkreldis.2020.06.084

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Journal: Parkinsonism and Related Disorders	Publication Date: Oct 1, 2020
Citations: 4

Affiliation: Heinrich Heine University Düsseldorf, Hamburg Institut (Germany), Universität Hamburg, University Medical Center Hamburg-Eppendorf, Royal Melbourne Hospital, Hospital Universitari Germans Trias i Pujol, Allegheny General Hospital, Cleveland Clinic, Hospital Universitario Virgen del Rocío, Albany Medical Center Hospital, Mount Sinai Hospital, Johannes Gutenberg University Mainz, Rush University Medical Center, Abbott (United States), Central University Hospital of Asturias

#Wider Therapeutic Window #Therapeutic Window #Prospective Crossover Study #Prospective Blinded Study #Directional Stimulation #Prospective Crossover #Range Of Amplitudes #Side Effects #Large Trial #Blinded Study

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Introduction: Published reports on directional DBS have been limited to small single-center investigations. Therapeutic window (TW) has been introduced in DBS to describe the range of stimulation amplitudes achieving symptom relief without side effects. The PROGRESS study evaluated whether directional DBS provides a wider TW in a large prospective trial.

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Directional versus omnidirectional Deep Brain Stimulation: Results of a multi-cente prospective blinded crossover study