Directing Traffic and Autophagy in Axonal Transport

Abstract

In this issue of Developmental Cell, Fu et al. (2014) address what determines persistent directional movement along microtubules of organelles capable of bidirectional transit. They show that retrograde axonal autophagosome transport is mediated by the scaffolding protein JIP1, which not only inhibits anterograde movement but may also promote autophagosome maturation.