Abstract
Direct thiophene arylation using a Heck-type reaction with Pd(OAc) 2 NBu 4Br as catalytic system is reported. Reactions with 2- and 3-substituted thiophenes have shown that substituent nature and position influence the cross-coupling. In particular, the substitution is regiospecific when the heterocycle is 2-substituted with an electron withdrawing group.
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