Abstract
Xeno-nucleic acids (XNAs), a class of nucleic acid molecules with unique backbones or nucleobases, have demonstrated exciting applications in molecule medicine, synthetic biology and material sciences due to their superior gene-silencing and catalytic activities. Unfortunately, XNA cannot be directly sequenced by any existing platform. Nanopore sequencing, which identifies a single molecule analyte directly from its physical and chemical properties, has promise for direct XNA sequencing. Here, direct XNA sequencing has been demonstrated using nanopore sequencing technology, and the performance of each single-molecule sequencing enzymatic reaction process is well monitored. Excitingly, this is the first attempt of nanopore technology in the XNA field, and it definitely leads to a promising future for a general sequencing method for the entire XNA family.
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