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Abstract
The direct resolution of baclofen (β- p-chlorophenyl-γ-aminobutyric acid) and a series of four analogues was achieved by HPLC on an enantioselective, crown ether column, CR(+). Chromatography was carried out with perchloric acid as mobile phase and methanol as organic modifier. The effects of temperature, pH, eluent composition and substituents are discussed. The absolute configuration is attributed. The best results were obtained with baclofen (α = 1.48; R s = 8.07).
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