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Abstract
The direct resolution of three analogues of baclofen (phaclofen, saclofen and hydroxysaclofen), potent -γ-aminobutyric acid B antagonists, is achieved by HPLC on an enantioselective crown ether column. The effects of the anionic group are discussed. Perchloric acid and methanol as organic modifier is used as mobile phase. The absolute configuration is proposed by comparison with enantiomers of baclofen (β- p-chlorophenyl-γ-aminobutyric acid). The above-mentioned compounds are easily and completely resolved.
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