Abstract
A chiral polymer easily obtained by treatment of a linear polyacrylamide with l-proline was adsorbed on a silica support treatment of a linear polyacrylamide with l-proline. After complexation with copper(II), and in spite of a rather low efficiency due to slow ligand exchange, such packings are very convenient for the resolution of amino acid enantiomers eluted in water (relative retentions, k′ L/ k′ D, higher than 2 may be observed). Other eluents may also be used. The chiral polymer was studied in solution by potentiometry and nuclear magnetic resonance spectroscopy ( 13C relaxation measurements). A model of the complex involved in the stereoselection is proposed which accounts for the chromatographic results obtained.
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