Abstract
AbstractRacemic tert‐leucine can be completely resolved by ligand exchange chromatography (LEC) using a Chiralpak WH column. The retention time of the tert‐leucine was decreased by increasing concentration of Cu2+, or decreasing pH of the eluent whereas it was unaffected by varying the temperature of eluent. Optimal conditions for complete separation of the D.L‐tert‐leucine were found to be (Cu2+, 5.0 mM, pH 5.5, 25 °C). The enantiomeric excess of synthetic tert‐leucine, a chiral auxiliary reagent, was determined.
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