Abstract
Optically pure (R)-2-(anthracen-9-yl)-2-methoxyacetic acid ((R)-9-AMA) was obtained. The most important stage of the synthesis generating chirality and ensuring high enantioselectivity was the stage of desymmetrization of prochiral α-ketoester. Enzymatic biotransformation was used in the presence of Saccharomyces cerevisiae and Aureobasidium pullulans. Biotransformation using S. cerevisiae leads to 65–70% enantiomeric excess (R-isomer). The antimycotic agent Boni Protect containing live cells of A. pullulans allowed to obtain enantiomerically pure (R)-9-AMA.
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