Abstract
Rabbit kidney cortex slices were used to investigate the effect of lithium chloride (0 to 20 mm) on renin release. Secretion of active renin was increased in the presence of lithium but inactive (acid‐activatable) renin secretion was unchanged. Increased plasma renin activity in patients receiving lithium therapy may be the result of direct effects of lithium on renin secretion mechanisms rather than being secondary to altered renal sodium handling.
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