Abstract
Methamphetamine enantiomers in drug abusers’ urine were clearly separated by semi-microcolumn liquid chromatography using a column-switching system. The system consists of two separation processes: firstly, a strong cation-exchange precolumn removes neutral and anionic substances in urine, and then methamphetamine enantiomers trapped in the column are transferred to and separated in a phenyl-β-cyclodextrin-bonded semi-microcolumn (Chiral Drug™, 150 mm×1.5 mm I.D.). ( S)-(+)-Methamphetamine was baseline separated from ( R)-(−)-methamphetamine within 25 min, directly from urine samples. The detection limit for both enantiomers was 0.1 μg/ml.
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