Direct Amidation of Alcohols with N‐Substituted Formamides under Transition‐Metal‐Free Conditions

Abstract

and C [9]H oxidative amidation, have alsoproven to be efficient methods for the construction of amidebonds.Although considerable progress has been made towardsmethods facilitating amide formation, efficient and low costsyntheses of N,N-dimethyl-substituted amides under metal-free conditions are still less explored. In general, the tradi-tional syntheses of N,N-dimethyl-substituted amides are lim-ited by the need for prior activation of carboxylic acids(Scheme 1a).