Abstract

The direct effects of melatonin on both testosterone production and cyclic nucleotide concentrations were studied using rat testis tissue in vitro . Melatonin inhibited testosterone production and stimulated both guanylate cyclase activity and c-GMP production, while c-AMP levels remained unchanged. These effects of melatonin on the testis appear to involve the Leydig cell fraction. It is suggested that melatonin acts directly on Leydig cell fraction to activate its guanylate cyclase, which converts GTP to c-GMP stimulating c-GMP production. Melatonin also inhibits steroidogenesis in rats testis tissue in vitro .

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.