Abstract
Dioctadecyldimethylammonium bromide (DODAB) is a double chain vesicle-forming cationic surfactant, whereas octa-ethyleneglycol mono- n-dodecyl ether (C 12E 8) is a single chain micelle-forming nonionic surfactant. At room temperature (ca. 22 °C) C 12E 8 molecules self-assemble in water as micelles while DODAB is insoluble. A mixture of DODAB and C 12E 8, however, can be soluble in water at room temperature depending on the relative amount of the compounds. We report the formation of small unilamellar vesicles (SUVs) by dialyzing at room temperature a mixture of 1.0 mM DODAB with 10 mM C 12E 8 in water. Extended bilayers are formed as well in equilibrium with vesicles. Such structures are viewed by a cryogenic transmission electron microscopy (cryo-TEM) image.
Published Version
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